Idebenone is an organic compound of the benzoquinone family. It is also marketed as a synthetic analogue of coenzyme Q10. There have also been trials that have proven their effects as a potent antioxidant. Idebenone is used to treat Alzheimer's disease and other cognitive disorders.
Idebenone is used to treat vision impairment in adults and adolescents with an eye disease called
Leber’s Hereditary Optic Neuropathy (LHON).
- This eye problem is inherited – this means it runs in families.
- It is caused by a problem with your genes (called a “genetic mutation”) that affects the ability of cells in the eye to produce the energy they need to work normally, so they become inactive.
- LHON can lead to loss of eyesight due to the inactivity of cells responsible for vision.
Treatment with Idebenone Tabletscan restore the ability of cells to produce energy and so allow inactive eye cells to work again. This can lead to some improvement in lost eyesight.
2. What you need to know before you take Idebenone
Do not take Idebenone :
- if you are allergic to idebenone or any of the other ingredients of this medicine (listed in section 6).
Warnings and precautions
Talk to your doctor or pharmacist before taking Idebenone Tablets if:
- you have any blood, liver or kidney problems.
Change in urine colour
Idebenone Tablets may make your urine become reddish brown. This change in colour is harmless – it does no mean your treatment needs to change. However, the change in colour could mean that you have problems with your kidneys or bladder.
- Tell your doctor if your urine changes colour.
- He or she may do a urine check to make sure the change in colour is not hiding other problems.
Your doctor will check your eye-sight before you start taking this medicine and then at regular visits while you are taking it.
Children and adolescents
This medicine should not be used in children This is because it is not known if Idebenone Tabletsis safe or works in patients under 12 years of age.
Other medicines and Idebenone
Some medicine may interact with Idebenone . Tell your doctor if you are taking, have recently taken or might take any other medicines, especially any of the following:
- to treat insomnia (midazolam, triazolam)
- to lower cholesterol levels or for prevention of cardiovascular disease (atorvastatin, lovastatin,
- antihistamines to treat allergies (astemizol, mizolastin, terfenadin)
- to treat high blood pressure and chest pain (bepridil, nisoldipin, ranolazine)
- to treat heartburn (cisaprid)
- to treat atrial fibrillation (dofetilid)
- for management of opioid dependence (levacetylmethadol)
- to treat muscle and speech tics associated with Tourette syndrome (pimozid)
- to treat hearth rhythm disorders (quinidine)
- antipsychotic medicines (sertindol)
- to treat migraine (dihydroergotamine, ergotamine, eletriptan)
- to control excesive bleeding after childbirth (ergometrin, methylergometrine).
Pregnancy and breast-feeding
If you are pregnant or breast-feeding, think you might be pregnant or are planning to have a baby, ask your doctor for advice before taking this medicine.
- Your doctor will prescribe Idebenone Tablets to you only if the benefits of the treatment are greater than the risks to the unborn child.
- Idebenone Tablets may pass into the mother’s milk. If you are breast-feeding your doctor will discuss with
you whether to stop breast-feeding or to stop taking the medicine. This will take into account
the benefit of breast-feeding to the child and the benefit of the medicine for you.
Driving and using machines
Idebenone Tablets is not expected to affect your ability to drive or use machines.
Idebenone Tablet scontains lactose and sunset yellow (E110)
- Idebenone Tablets contains lactose (a type of sugar). If you have been told by your doctor that you have lactose intolerance or that you cannot tolerate or digest some sugars, talk to your doctor before
taking this medicine.
- Idebenone Tablets contains a colourant called “sunset yellow” (also called E110). This may cause allergic reactions.
3. How to take Idebenone
Always take this medicine exactly as your doctor or pharmacist has told you. Check with your doctor
or pharmacist if you are not sure.
How much to take Idebenone
The recommended dose is 2 tablets three times a day - this is a total of 6 tablets per day.
Taking this medicine
- Take the tablets with food - this helps to get more of the medicine from your stomach into your
- Swallow the tablets whole with a glass of liquid.
- Do not crush or chew the tablets.
- Take the tablets at the same time of day each day. For example in the morning at breakfast, with
lunch at mid-day and with dinner in the evening.
If you take more Idebenone Tablets than you should
If you take more Idebenone Tablets than you should, talk to your doctor straight away.
If you forget to take Idebenone
If you forget a dose, skip the missed dose. Take the next dose at the usual time.
Do not take a double dose to make up for a forgotten dose.
If you stop taking Idebenone
Talk to your doctor before you stop taking this medicine.
If you have any further questions on the use of this medicine, ask your doctor or pharmacist.
4. Possible side effects
Like all medicines, this medicine can cause side effects, although not everybody gets them. The following side effect may happen with this medicine: