Buy Pramipexole Online 1mg 100 Tablets
Pramipexole is a dopamine agonist and is used to treat Parkinson's disease, either in monotherapy or in combination with L-DOPA. Another indication is the symptomatic treatment of moderate-to-severe idiopathic restless legs syndrome. Furthermore, studies have shown pramipexole to be efficacious in the treatment of bipolar disorders.
Pramipexole is a dopamine agonist with high selectivity and specificity at D2 / 3 dopamine receptors. In the early stages of Parkinson's disease, pramipexole stimulates pre-synaptic D2 autoreceptors, thereby inhibiting excessive dopamine synthesis and release. In the late stage, pramipexole potentiates the onset of dopamine synthesis by stimulating and modulating postsynaptic D2 and D3 receptors.
Pramipexole is recommended as a standard of care in the guidelines of the German Neurological Society in patients with Parkinson's disease younger than 70 years. Pramipexole may improve depressive symptoms in early Parkinson's disease patients.
Risks and side effects
Since it has no ergoline structure, unlike the ergot alkaloids, no pleuropulmonalen and retroperitoneal fibroses or peripheral vascular side effects are to be feared.
Due to the occurrence of possible "sleep attacks", the driving of a motor vehicle or the execution of work with a potential risk of injury among nonergoline dopamine agonists (pramipexole, ropinirole) is to be omitted.
The term "sleep attack" refers to an increased imperative need for sleep with, however, otherwise also lower vigilance and increased drowsiness and is not identical with the concept of the actual sleep attack in narcolepsy. It should also be considered that sleep disorders already occur as a result of Parkinson's disease and "sleep attacks" can also occur in healthy people. However, when treated with pramipexole and ropinirole, increased evidence of o. G. Sleep attacks has come is discouraged by driving a car. A pathophysiological relationship with the activation of D3 receptors is discussed.
Often the occurrence of impulse control disorders (eg, gambling addiction, buying addiction).
The treatment of Restless Legs Syndrome with pramipexole can lead to an aggravation of the symptoms (so-called rebound or augmentation effects). Similar interferences are known from L-DOPA and other dopamine agonists.