Buy Online Levothyroxine Sodium T3 (Tefor Duotab) 0.1 mg 100 Tablets
Levothyroxine, is a synthetic form of thyroxine (thyroid hormone), used as a hormone replacement in patients with thyroid problems . The natural hormone is chemically presented under the chiral form L, just like the pharmaceutical agent. Dextrothroxin (D-thyroxine) was briefly investigated as a possible anticholesterol agent, but was withdrawn due to cardiac side effects.
Levothyroxine has an effect similar to the natural thyroid hormone: it transforms into T3 in the peripheral organs and, like the endogenous hormone, develops its action in T3 receptors; and the organism is unable to appreciate between endogenous and exogenous levothyroxine.
The EU has recently standardized the use of the name "levothyroxine" for the drug. Common trademarks include in Europe "Thyrax", "Euthyrox", "Levaxin", "Eltroxin"; in EE. UU. "Levoxyl" and "Synthroid".
There are numerous versions of generics approved by national agencies, such as the American FDA.
In this leaflet
1 What Levothyroxine is and what it is used for
2 Before you take
3 How to take
4 Possible side effects
5 How to store
6 Further information
Thyroxine is a hormone which is produced naturally in the body by the thyroid gland. Levothyroxine is a synthetic version of this hormone. Thyroxine controls how much energy your body uses. When the thyroid gland does not produce enough thyroxine (a condition known as hypothyroidism), many of the body’s functions slow down. Some of the most common symptoms of hypothyroidism are:
Levothyroxine tablets are used to replace the thyroxine that your thyroid gland cannot produce and prevent the symptoms of hypothyroidism. Before starting your treatment your doctor will carry out a blood test to work out how much levothyroxine you need.
Do not take this medicine if you:
Check with your doctor or pharmacist before taking Levothyroxine tablets if you:
Before you start taking levothyroxine your doctor will do a blood test to see how much thyroxine your thyroid gland is making and what dose of the medicine you will need. Once you start taking the medicine your doctor will want you to have regular blood tests to see how well the medicine is working.
Taking other medicines
Many medicines affect the way levothyroxine works. The effects of other drugs may also be affected by levothyroxine.
You must tell your doctor if you are taking or start taking any other medicines, including over the counter medicines, herbal remedies and vitamin supplements.
The following may affect the way that levothyroxine works:
The following may be affected by levothyroxine:
Pregnancy and breast-feeding
If you are pregnant particularly in the first three months of your pregnancy, planning to become pregnant or are breast-feeding, tell your doctor or pharmacist before taking this medicine. Your doctor will decide if you should continue treatment with levothyroxine whilst you are pregnant.
Important information about some of the ingredients
If you have been told by your doctor that you have an intolerance to some sugars, contact your doctor before taking this medicine, as it contains lactose.
You may be taking this medicine for the rest of your life. Always take Levothyroxine tablets exactly as your doctor has told you. If you are not sure, check with your doctor or pharmacist. Your dose will be decided by your doctor and will depend on the results of your blood tests. The dose you should take will be on the label attached by your pharmacist. Swallow the tablets with plenty of water. You should usually take your tablets before breakfast or your first meal of the day.
The usual starting dose is 50-100 micrograms every day. Your doctor may increase the dose you take every 3-4 weeks by 50 micrograms until your thyroxine levels are correct. Your final daily dose may be up to 100-200 micrograms daily.
Patients over 50 years of age:
The usual starting dose will be no more than 50 micrograms every day. The dose may then be increased by 50 micrograms every 3-4 weeks until your thyroxine levels are correct. Your final daily dose will be between 50-200 micrograms daily.
Patients over 50 years with heart problems:
The starting dose will be 25 micrograms every day or 50 micrograms every other day. The dose may be increased by 25 micrograms every 4 weeks until your thyroxine levels are correct. Your final daily dose will usually be between 50-200 micrograms daily.
Giving these tablets to children:
The dose for children depends on their age, weight and the condition being treated. Your child will be monitored to make sure he/she gets the right dose. You should give them their medicine at least half an hour before breakfast or their first meal of the day. If necessary, the tablets can be dissolved in 10-15ml of water and given with some more liquid (5-10ml). The dissolved tablets should be taken straight away. Do not keep the solution to give to your child later.
Congenital hypothyroidism in infants:
This is a condition where your baby has been born with a thyroid gland that does not produce enough thyroxine. The starting dose is 10 -15 micrograms/kg bodyweight per day for the first three months. The dose will then be adjusted depending on how your baby responds to the treatment.
Acquired hypothyroidism in children:
This is a condition where your child’s thyroid gland stops working properly because it has been attacked by their immune system, e.g. in children with an autoimmune disease or following a viral infection. The starting dose is 12.5 to 50 micrograms a day. The dose should be increased gradually every 2 to 4 weeks depending on how your child responds to the medicine.
This is a condition where children and adolescents develop severe hypothyroidism (produce very low levels of thyroid hormones). The starting dose is 25 micrograms every day. The dose will then be increased by 25 micrograms every 2-4 weeks until your child shows mild symptoms of hyperthyroidism (a condition where the thyroid gland produces too much thyroxine). The dose will then be reduced slightly.
In children over 1 year, initially 2.5-5 micrograms per kg of bodyweight a day should be taken.
If you take more Levothyroxine than you should
If you (or someone else) swallow a lot of the tablets at the same time, or you think a child may have swallowed any, contact your nearest hospital casualty department or tell your doctor immediately. Signs of an overdose may include: fever, chest pain (angina), racing or irregular heartbeat, muscle cramps, headache, restlessness, flushing, sweating and diarrhoea. These signs can take up to 5 days to appear.
If you forget to take Levothyroxine
If you forget to take a dose take it as soon as you remember unless it is nearly time for your next dose. Do not take a double dose. If you forget to give your child their dose, contact your doctor or pharmacist for further advice.
Stopping the tablets:
These tablets are for long term use. You may need to take them for the rest of your life. Do not stop taking the tablets unless your doctor has told you to do so.
Some people may have side-effects when taking this medicine.
Stop taking the tablets and go to hospital at once if you have:
Some patients may experience a severe reaction to high levels of thyroid hormone. This is called a “thyroid crisis” and you should contact your doctor immediately if you have any of the following symptoms:
Tell your doctor or pharmacist if any of the following side effects continue, get worse or if you notice any other side effects not listed.
Most of the side effects are similar to the symptoms of hyperthyroidism (where the thyroid gland makes too much throxine) and are due to your dose of the medicine being too high. They will usually disappear after reducing the dose or stopping the tablets. However, you must not change the dose or stop the tablets without talking to your doctor first.
Reporting of side effects
If you get any side effects, talk to your doctor, pharmacist or nurse. This includes any possible side effects not listed in this leaflet. You can also report side effects directly via the Yellow Card Scheme at: www.mhra.gov.uk/yellowcard
By reporting side effects you can help provide more information on the safety of this medicine.
What Levothyroxine tablets contain
What Levothyroxine tablets look like and contents of the pack
50 microgram tablets are white, circular, biconvex, uncoated tablets.
100 microgram tablets are white, circular, shallow convex, uncoated tablets.
Pack size is 28 and 1000 tablets.
Marketing Authorisation Holder and Manufacturer
This leaflet was last revised in February 2017
If you would like a leaflet with larger text, please contact 01271 385257.