Buy Humalog Online (Insulin Lispro) 100/IU/ml 3 ml 5 Cartilages
Insulin lispro (brand name Humalog) is a fast-acting insulin analogue. Humalog was marketed by Lilly in 1996  as the first insulin analogue by far. Humalog works within 15 minutes and has about 2 to 5 hours duration, with an optimal duration is about 1 hours
What Humalog is and what it is used for
Humalog is used to treat diabetes. Humalog works more quickly than normal human insulin because the insulin molecule has been changed slightly.
You get diabetes if your pancreas does not make enough insulin to control the level of glucose in your blood. Humalog is a substitute for your own insulin and is used to control glucose in the long term. It works very quickly and lasts a shorter time than soluble insulin (2 to 5 hours). You should normally use Humalog within 15 minutes of a meal. Your doctor may tell you to use Humalog as well as a longer-acting insulin. Each kind of insulin comes with another patient information leaflet to tell you about it. Do not change your insulin unless your doctor tells you to. Be very careful if you do change insulin. Humalog is suitable for use in adults and children. Humalog may be used in children, when an advantage is expected compared to soluble insulin, for example, in the timing of the injection in relation to meals.
What you need to know before you use Humalog
Do NOT use Humalog
- if you think hypoglycaemia (low blood sugar) is starting. Further in this leaflet it tells you how to deal with mild hypoglycaemia (see section 3: If you take more Humalog than you need).
- if you are allergic (hypersensitive) to insulin lispro or any of the other ingredients of this medicine.
Warnings and precautions
If your blood sugar levels are well controlled by your current insulin therapy, you may not feel the warning symptoms when your blood sugar is falling too low. Warning signs are listed later in this leaflet. You must think carefully about when to have your meals, how often to exercise and how much to do. You must also keep a close watch on your blood sugar levels by testing your blood glucose often.
A few people who have had hypoglycaemia after switching from animal insulin to human insulin have reported that the early warning symptoms were less obvious or different. If you often have hypoglycaemia or have difficulty recognising it, please discuss this with your doctor.
If you answer YES to any of the following questions, tell your doctor, pharmacist or diabetes nurse
- Have you recently become ill?
- Do you have trouble with your kidneys or liver?
- Are you exercising more than usual?
The amount of insulin you need may also change if you drink alcohol.
You should also tell your doctor, pharmacist or diabetes nurse if you are planning to go abroad. The time difference between countries may mean that you have to have your injections and meals at different times from when you are at home.
Some patients with long-standing type 2 diabetes mellitus and heart disease or previous stroke who were treated with pioglitazone and insulin experienced the development of heart failure. Inform your doctor as soon as possible, if you experience signs of heart failure such as unusual shortness of breath or rapid increase in weight or localised swelling (oedema).
If the 40 units/ml vial is the product normally prescribed, do not take insulin from a 100 units/ml cartridge using a 40 units/ml syringe.
Other medicines and Humalog
Your insulin needs may change if you are taking
the contraceptive pill,
thyroid hormone replacement therapy,
acetyl salicylic acid,
“beta2 stimulants” (for example ritodrine, salbutamol or terbutaline),
some antidepressants (monoamine oxidase inhibitors or selective serotonin reuptake inhibitors),
some angiotensin converting enzyme (ACE) inhibitors (for example captopril, enalapril), and
angiotensin II receptor blockers.
Please tell your doctor, if you are taking or have recently taken any other medicines, including medicines obtained without a prescription (see section “Warnings and precautions”).
Pregnancy and breast-feeding
Are you pregnant or thinking about becoming pregnant, or are you breast-feeding? The amount of insulin you need usually falls during the first three months of pregnancy and increases for the remaining six months. If you are breast-feeding, you may need to alter your insulin intake or diet.
Ask your doctor for advice.
Driving and using machines
Your ability to concentrate and react may be reduced if you have hypoglycaemia. Please keep this possible problem in mind in all situations where you might put yourself and others at risk (e.g. Driving a car or operating machinery). You should contact your doctor about the advisability of driving if you have:
frequent episodes of hypoglycaemia
reduced or absent warning signs of hypoglycaemia
How to use Humalog
The 3 ml cartridge is only for use in 3ml pens. It is not for use in 1.5 ml pens.
Always check the pack and the cartridge label for the name and type of the insulin when you get it from your pharmacy. Make sure you get the Humalog that your doctor has told you to use.
Always use Humalog exactly as your doctor has told you. You should check with your doctor if you are not sure. To prevent the possible transmission of disease, each cartridge must be used by you only, even if the needle on the delivery device is changed.
You should normally inject Humalog within 15 minutes of a meal. If you need to, you can inject soon after a meal. But your doctor will have told you exactly how much to use, when to use it, and how often. These instructions are only for you. Follow them exactly and visit your diabetes clinic regularly.
If you change the type of insulin you use (for example from a human or animal insulin to a Humalog product), you may have to take more or less than before. This might just be for the first injection or it may be a gradual change over several weeks or months.
Inject Humalog under the skin. You should only inject it into a muscle if your doctor has told you to.
Humalog is already dissolved in water, so you do not need to mix it. But you must use it only if it looks like water. It must be clear, have no colour and no solid pieces in it. Check each time you inject yourself.
Getting the pen ready to use
First wash your hands. Disinfect the rubber membrane of the cartridge.
You must only use Humalog cartridges in compatible CE marked pens. Please make sure that Humalog or Lilly cartridges are mentioned in the leaflet accompanying your pen. The 3 ml cartridge only fits the 3 ml pen.
Follow the instructions that come with the pen. Put the cartridge into the pen.
You will set the dose to 1 or 2 units. Then hold the pen with the needle pointing up and tap the side of the pen so that any bubbles float to the top. With the pen still pointing up, press the
injection mechanism. Do this until a drop of Humalog comes out of the needle. There may still be some small air bubbles left in the pen. These are harmless, but if the air bubble is too big, it may make the dose of your injection less accurate.
Before you make an injection, clean your skin as you have been instructed. Inject under the skin, as you were taught. Do not inject directly into a vein. After your injection, leave the needle in the skin for five seconds to make sure you have taken the whole dose. Do not rub the area you have just injected. Make sure you inject at least half an inch (1 cm) from the last injection and that you ‘rotate’ the places you inject, as you have been taught. It doesn’t matter which injection site you use, either upper arm, thigh, buttock or abdomen, your Humalog injection will still work quicker than soluble human insulin.
You must not administer Humalog by the intravenous route. Inject Humalog as your physician or nurse has taught you. Only your physician can administer Humalog by the intravenous route.
He will only do this under special circumstances such as surgery or if you are ill and your glucose levels are too high.
As soon as you have done the injection, take the needle off the pen using the outer needle cap. This will keep the Humalog sterile and prevent leaking. It will also stop air going back into the pen and the needle clogging up. Do not share your needles. Do not share your pen. Replace the cap on your pen. Leave the cartridge in the pen.
Before every injection, dial 1 or 2 units and press the injection mechanism with the pen
pointing up until a drop of Humalog comes out of the needle. You can see how much Humalog is left by looking at the gauge on the side of the cartridge. The distance between each mark on the gauge is about 20 units. If there is not enough for your dose, change the cartridge.
Do not mix any other insulin in a Humalog cartridge. Once the cartridge is empty, do not use it again.
Using Humalog in an infusion pump
Only certain CE-marked insulin infusion pumps may be used to infuse insulin lispro. Before infusing insulin lispro, the manufacturers instructions should be studied to ascertain the suitability or otherwise for the particular pump. Read and follow the instructions in the product literature supplied with the infusion pump.
Be sure to use the correct reservoir and catheter for your pump.
Changing of the infusion set (tubing and needle) must be done according to the instructions in the product information supplied with the infusion set.
In the event of a hypoglycaemic episode, the infusion should be stopped until the episode is resolved. If repeated or severe low blood glucose levels occur, notify your doctor or clinic and consider the need to reduce or stop your insulin infusion.
A pump malfunction or obstruction of the infusion set can result in a rapid rise in glucose levels. If an interruption to insulin flow is suspected, follow the instructions in the product literature and if appropriate, notify your doctor or clinic.
When used with an insulin infusion pump, Humalog should not be mixed with any other insulin.
If you take more Humalog than you need
If you take more Humalog than you need, a low blood sugar may occur. Check your blood sugar. If your blood sugar is low (mild hypoglycaemia), eat glucose tablets, sugar or drink a sugary drink. Then eat fruit, biscuits, or a sandwich, as your doctor has advised you and have some rest. This will often get you over mild hypoglycaemia or a minor insulin overdose. If you get worse and your breathing is shallow and your skin gets pale, tell your doctor at once. A glucagon injection can treat quite severe hypoglycaemia. Eat glucose or sugar after the glucagon injection. If you do not respond to glucagon, you will have to go to hospital. Ask your doctor to tell you about glucagon.
If you forget to use Humalog
If you take less Humalog than you need, a high blood sugar may occur. Check your blood sugar. If hypoglycaemia (low blood sugar) or hyperglycaemia (high blood sugar) is not treated they can be very serious and cause headaches, nausea, vomiting, dehydration, unconsciousness, coma or even death (see A and B in section 4 “Possible Side Effects”).
Three simple steps to avoid hypoglycaemia or hyperglycaemia are:
• Always keep spare syringes and a spare vial of Humalog, or a spare pen and cartridges, in case you lose your pen or cartridges or they get damaged.
• Always carry something to show you are diabetic.
• Always carry sugar with you.
If you stop using Humalog.
If you take less Humalog than you need, a high blood sugar may occur. Do not change your insulin unless your doctor tells you to.
If you have any further questions on the use of this product, ask your doctor or pharmacist.
Possible side effects
Like all medicines, Humalog can cause side effects, although not everybody gets them.
Local allergy is common ( 1/100 to <1/10). Some people get redness, swelling or itching around the area of the insulin injection. This usually clears up in anything from a few days to a few weeks. If this happens to you, tell your doctor.
Systemic allergy is rare ( 1/10,000 to <1/1,000). The symptoms are as follows:
• rash over the whole body • blood pressure dropping
• difficulty in breathing • heart beating fast
• wheezing • sweating
If you think you are having this sort of insulin allergy with Humalog, tell your doctor at once.
Lipodystrophy (thickening or pitting of the skin) is uncommon ( 1/1,000 to <1/100). If you notice your skin thickening or pitting at the injection site, tell your doctor.
Oedema (e.g. swelling in arms, ankles; fluid retention) has been reported, particularly at the start of insulin therapy or during a change in therapy to improve control of your blood glucose.
Reporting of side effects
If you get any side effects, talk to your doctor or pharmacist. This includes any possible side effects not listed in this leaflet. You can also report side effects directly via Ireland: HPRA
Pharmacovigilance, Earlsfort Terrace, IRL - Dublin 2, Tel: +353 1 6764971, Fax: +353 1 6762517,
website: www.hpra.ie, e-mail: firstname.lastname@example.org, Malta: ADR Reporting, website:
www.medicinesauthority.gov.mt/adrportal, or the United Kingdom: Yellow Card Scheme, website:
www.mhra.gov.uk/yellowcard. By reporting side effects you can help provide more information on the safety of this medicine.
Common problems of diabetes
Hypoglycaemia (low blood sugar) means there is not enough sugar in the blood. This can be caused
• you take too much Humalog or other insulin;
• you miss or delay meals or change your diet;
• you exercise or work too hard just before or after a meal;
• you have an infection or illness (especially diarrhoea or vomiting);
• there is a change in your need for insulin; or
• you have trouble with your kidneys or liver which gets worse.
Alcohol and some medicines can affect your blood sugar levels.
The first symptoms of low blood sugar usually come on quickly and include the following:
• rapid heartbeat
• nervousness or shakiness
• feeling sick
• cold sweat
While you are not confident about recognising your warning symptoms, avoid situations, e.g. driving
a car, in which you or others would be put at risk by hypoglycaemia.
B. Hyperglycaemia and diabetic ketoacidosis
Hyperglycaemia (too much sugar in the blood) means that your body does not have enough insulin.
Hyperglycaemia can be brought about by:
• not taking your Humalog or other insulin;
• taking less insulin than your doctor tells you to;
• eating a lot more than your diet allows; or
• fever, infection or emotional stress.
Hyperglycaemia can lead to diabetic ketoacidosis. The first symptoms come on slowly over many hours or days. The symptoms include the following:
• feeling sleepy • no appetite
• flushed face • fruity smell on the breath
• thirst • feeling or being sick
Severe symptoms are heavy breathing and a rapid pulse. Get medical help immediately.
If you are ill, especially if you feel sick or are sick, the amount of insulin you need may change. Even when you are not eating normally, you still need insulin. Test your urine or blood, follow your ‘sick rules’, and tell your doctor.
How to store Humalog
Before the first use store your Humalog in a refrigerator (2C – 8C). Do not freeze.
Keep your cartridge in use at room temperature (15° - 30°C) and discard after 28 days. Do not put it near heat or in the sun. Do not keep your pen or the cartridges you are using in the fridge. The pen with the inserted cartridge should not be stored with the needle attached.
Keep out of the reach and sight of children.
Do not use Humalog after the expiry date which is stated on the label and the carton. The expiry date refers to the last day of that month.
Do not use Humalog, if it is coloured or it has solid pieces in it. You must use it only if it looks like water. Check this each time you inject yourself.
Medicines should not be disposed of via wastewater or household waste. Ask your pharmacist how to dispose of medicines no longer required. These measures will help to protect the environment.
Contents of the pack and other information
What Humalog 100 units/ml solution for injection in cartridge contains
- The active substance is insulin lispro. Insulin lispro is made in the laboratory by a ‘recombinant DNA technology’ process. It is a changed form of human insulin and so is different from other human and animal insulins. Insulin lispro is closely related to human insulin which is a natural hormone made by the pancreas.
- The other ingredients are m-cresol, glycerol, dibasic sodium phosphate 7 H2O, zinc oxide and water for injection. Sodium hydroxide or hydrochloric acid may have been used to adjust the acidity.
What Humalog looks like and contents of the pack
Humalog 100 units/ml, solution for injection is a sterile, clear, colourless, aqueous solution and ontains 100 units of insulin lispro in each millilitre (100 units/ml) solution for injection. Each cartridge contains 300 units (3 millilitres). The cartridges come in packs of 5 or 10 cartridges.